Vitamin D status and markers of bone turnover in Caucasian and South Asian postmenopausal women living in the UK.
Br J Nutr
; 103(12): 1706-10, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20102676
ABSTRACT
Suboptimal vitamin D status among the South Asian UK population is widely reported; however, its impact on bone health is unclear. The aim of the present study was to conduct a comparative investigation of vitamin D status in postmenopausal South Asian (SA) and Caucasian (C) women and its relationship to parathyroid hormone (PTH) concentration, biochemical markers of bone turnover and bone quality. A cross-sectional study of community-dwelling women aged 50-66 years was carried out. A total of sixty-six SA women of Pakistani origin and forty-two C women living in the same community were recruited. Fasting blood was taken for the measurement of vitamin D, PTH and biochemical markers of bone turnover, including type-1 collagen beta C-telopeptide (betaCTX), procollagen type-1 amino-terminal propeptide (P1NP), and bone-specific alkaline phosphatase (BAP) activity. Bone quality was assessed using broadband ultrasound attenuation (BUA). Total serum 25-hydroxyvitamin D (25(OH)D) was significantly lower in the SA women than the C women (medians SA 10.5 v. C 47.1 nmol/l; P < 0.001) This was associated with a significantly elevated serum PTH concentration in the SA group (medians SA 7.3 v. C 4.5 pmol/l; P < 0.01). BAP activity was also significantly higher in the SA group, indicating elevated osteoblast activity and bone turnover (medians SA 23.0 v. C 20.0 U/l; P < 0.05). No significant differences were observed between the two groups for P1NP, betaCTX or BUA. Although the SA women had significantly higher serum PTH and lower 25(OH)D concentrations than C women, this was not associated with significantly higher markers of bone resorption, or reduced bone quality in the SA women.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Hormônio Paratireóideo
/
Vitamina D
/
Deficiência de Vitamina D
/
Reabsorção Óssea
/
Densidade Óssea
/
Conservadores da Densidade Óssea
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Middle aged
País/Região como assunto:
Asia
/
Europa
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article