Blocking the deadly effects of the NMDA receptor in stroke.
Cell
; 140(2): 174-6, 2010 Jan 22.
Article
em En
| MEDLINE
| ID: mdl-20141829
ABSTRACT
Excessive activation of NMDA glutamate receptors contributes to neuronal death after stroke. In this issue, Tu et al. (2010) demonstrate that ischemic injury promotes the association of death-associated protein kinase 1 with the NMDA receptor, thereby potentiating its activity, and show that disrupting this association reduces damage to the brain.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de N-Metil-D-Aspartato
/
Proteínas Quinases Dependentes de Cálcio-Calmodulina
/
Acidente Vascular Cerebral
/
Proteínas Reguladoras de Apoptose
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article