A strategy for analyzing gene-nutrient interactions in type 2 diabetes.
J Diabetes Sci Technol
; 3(4): 710-21, 2009 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-20144318
ABSTRACT
Type 2 diabetes mellitus (T2DM), like all chronic diseases, results from interactions between multiple genes and multiple environmental factors. Nevertheless, many research studies focus on either nutrition or genetic factors independently of each other. The challenges of analyzing gene-nutrient interactions in T2DM are the (i) genetic heterogeneity in humans, (ii) complexity of environmental factors, particularly dietary chemicals, and (iii) diverse physiologies that produce the same apparent disease. Many of these variables are not accounted for in the design or study of T2DM or, indeed, most chronic diseases, although exceptions are noteworthy. Establishing experimental paradigms to analyze the complexity of these interactions and physiologies is challenging, but possible. This article provides a strategy to extend nutrigenomic experimental strategies to include early environmental influences that may promote adult-onset disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Mellitus Tipo 2
/
Dieta
/
Nutrigenômica
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article