Markov random fields reveal an N-terminal double beta-propeller motif as part of a bacterial hybrid two-component sensor system.
Proc Natl Acad Sci U S A
; 107(9): 4069-74, 2010 Mar 02.
Article
em En
| MEDLINE
| ID: mdl-20147619
ABSTRACT
The recent explosion in newly sequenced bacterial genomes is outpacing the capacity of researchers to try to assign functional annotation to all the new proteins. Hence, computational methods that can help predict structural motifs provide increasingly important clues in helping to determine how these proteins might function. We introduce a Markov Random Field approach tailored for recognizing proteins that fold into mainly beta-structural motifs, and apply it to build recognizers for the beta-propeller shapes. As an application, we identify a potential class of hybrid two-component sensor proteins, that we predict contain a double-propeller domain.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
Tipo de estudo:
Clinical_trials
/
Health_economic_evaluation
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article