Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists.

He, Shuwen; Dobbelaar, Peter H; Liu, Jian; Jian, Tianying; Sebhat, Iyassu K; Lin, Linus S; Goodman, Allan; Guo, Cheng; Guzzo, Peter R; Hadden, Mark; Henderson, Alan J; Ruenz, Megan; Sargent, Bruce J; Yet, Larry; Kelly, Theresa M; Palyha, Oksana; Kan, Yanqing; Pan, Jie; Chen, Howard; Marsh, Donald J; Shearman, Lauren P; Strack, Alison M; Metzger, Joseph M; Feighner, Scott D; Tan, Carina; Howard, Andrew D; Tamvakopoulos, Constantin; Peng, Qianping; Guan, Xiao-Ming; Reitman, Marc L; Patchett, Arthur A; Wyvratt, Matthew J; Nargund, Ravi P

He, Shuwen; Dobbelaar, Peter H; Liu, Jian; Jian, Tianying; Sebhat, Iyassu K; Lin, Linus S; Goodman, Allan; Guo, Cheng; Guzzo, Peter R; Hadden, Mark; Henderson, Alan J; Ruenz, Megan; Sargent, Bruce J; Yet, Larry; Kelly, Theresa M; Palyha, Oksana; Kan, Yanqing; Pan, Jie; Chen, Howard; Marsh, Donald J; Shearman, Lauren P; Strack, Alison M; Metzger, Joseph M; Feighner, Scott D; Tan, Carina; Howard, Andrew D; Tamvakopoulos, Constantin; Peng, Qianping; Guan, Xiao-Ming; Reitman, Marc L; Patchett, Arthur A; Wyvratt, Matthew J; Nargund, Ravi P.

Afiliação

He S; Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. shuwen_he@merck.com

Bioorg Med Chem Lett ; 20(6): 1913-7, 2010 Mar 15.

Article em En | MEDLINE | ID: mdl-20167483

Assuntos

Descoberta de Drogas; Imidazóis/química; Imidazóis/farmacologia; Receptores da Bombesina/agonistas; Animais; Disponibilidade Biológica; Humanos; Imidazóis/farmacocinética; Ratos; Relação Estrutura-Atividade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores da Bombesina / Descoberta de Drogas / Imidazóis Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article

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