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Comparison of colonoscopy and fecal occult blood testing as a first-line screening of colonic lesions in patients with newly diagnosed acromegaly.
Bogazzi, F; Lombardi, M; Scattina, I; Urbani, C; Marciano, E; Costa, A; Pepe, P; Rossi, G; Martino, E.
Afiliação
  • Bogazzi F; Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124, Pisa, Italy. f.bogazzi@endoc.med.unipi.it
J Endocrinol Invest ; 33(8): 530-3, 2010 Sep.
Article em En | MEDLINE | ID: mdl-20186003
ABSTRACT
CONTENT Patients with acromegaly have frequently colonic neoplasms; however, how acromegalic patients should be screened for colonic lesions is still unsettled.

AIMS:

To compare fecal occult blood testing (FOBT) and colonoscopy in the screening program of patients with acromegaly.

DESIGN:

Colonoscopy and FOBT were performed at the first diagnosis of acromegaly.

SETTING:

Tertiary University center. PATIENTS Eighty-five consecutive patients with untreated active acromegaly submitted to colonoscopy and FOBT.

RESULTS:

FOBT, which was positive in 16 (18.8%) out of 85 patients, identified 2 patients with colonic adenocarcinoma and 2 with adenoma; the remaining 12 patients had no detectable colonic lesions. Colonoscopy revealed colonic lesions in 29 patients 3 (3.5%) cancers, 11 (12.9%) adenomas, and 15 (17.6%) hyperplastic polyps. The remaining 56 acromegalic patients had no detectable lesions. A patient with cancer and 9 patients with adenoma were missed if screened only by FOBT.

CONCLUSIONS:

Colonoscopy is superior to FOBT in detecting colonic lesions at the first diagnosis of acromegaly.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acromegalia / Pólipos do Colo / Colonoscopia / Neoplasias do Colo / Sangue Oculto Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acromegalia / Pólipos do Colo / Colonoscopia / Neoplasias do Colo / Sangue Oculto Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2010 Tipo de documento: Article