Cortical dopamine D2/D3 receptors and verbal memory in man.
Neuroimage
; 51(2): 918-22, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20188195
ABSTRACT
INTRODUCTION:
It has been previously reported that hippocampal dopamine D2/D3 receptors are involved in the regulation of verbal memory and learning in healthy volunteers. We tested this hypothesis further and studied whether cortical dopamine D2/D3 receptor availability in vivo is associated with verbal memory as assessed with the revised Wechsler Memory Scale (WMS-R).METHODS:
Forty healthy Finnish subjects were evaluated according to the WMS-R and scanned with positron emission tomography (PET) and dopamine D2/D3 receptor radioligand [(11)C]FLB457 for the measurement of cortical D2/D3 receptor binding.RESULTS:
WMS-R verbal memory and learning parameters did not significantly correlate with D2/D3 receptor binding potential (BP(ND)) in the studied cortical regions.CONCLUSIONS:
Our findings do not support a major role for cortical D2/D3 receptors in the regulation of verbal memory in healthy individuals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Verbal
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Córtex Cerebral
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Receptores de Dopamina D2
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Receptores de Dopamina D3
/
Memória
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article