The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist.
Bioorg Med Chem Lett
; 20(7): 2340-3, 2010 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-20202837
ABSTRACT
The identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A selective over PR is described. Associated structure-activity relationships and the process of optimisation of an initial HTS hit are also described.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Glucocorticoides
/
Bibliotecas de Moléculas Pequenas
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article