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CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.
Bhagawati-Prasad, Vijay Ns; De Leenheer, Evy; Keefe, Nadine P; Ryan, Lorna A; Carlring, Jennifer; Heath, Andrew W.
Afiliação
  • Bhagawati-Prasad VN; Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
  • De Leenheer E; Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
  • Keefe NP; Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
  • Ryan LA; Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
  • Carlring J; Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
  • Heath AW; Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
J Immune Based Ther Vaccines ; 8: 1, 2010 Feb 04.
Article em En | MEDLINE | ID: mdl-20205811
ABSTRACT
Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2010 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2010 Tipo de documento: Article