Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification.
Bioorg Med Chem Lett
; 20(7): 2200-3, 2010 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-20207145
ABSTRACT
Orthoesters are acid-sensitive moieties that allow substantial structural diversity for biological applications including drug delivery. Here, the pH-sensitivity of a range of novel orthoester based compounds was compared in the range 7.5-4.5 that is characteristic of the increased acidification during endocytosis. We find that simple modifications close to the orthoester had major effects on both the rate and extent of hydrolysis, suggesting this could be exploited for activating drug delivery systems on endocytic pathways.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Portadores de Fármacos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article