[Leukocyte stimulation by DNA fragments shored up protamine in cyclophosphamide-induced leukopoiesis in mice].
Vopr Onkol
; 55(6): 761-4, 2009.
Article
em Ru
| MEDLINE
| ID: mdl-20210022
ABSTRACT
Our study showed that protamine (80% w/w to DNA) effectively protected its molecules from degradation by native nucleases of the mammalian blood serum. Exogenous DNA bound to protamine effectively stimulated restoration of cyclophosphamide-induced leukopoiesis in mice. It is suggested that the phenomenon was due to repair processes taking place in hemopoietic stem cells damaged by a cross-linking cytostatic drug such as cyclophosphamide. DNA dosage may be reduced and the original DNA fragment size maintained by DNA binding to protamine. As a result, it might involve longer DNA fragments into repair processes of homologous recombination and eventually increase the cell's chances of getting rid of extensive damage.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Protaminas
/
Leucopoese
/
Ciclofosfamida
/
Fragmentação do DNA
/
Imunossupressores
/
Leucócitos
Limite:
Animals
/
Humans
/
Male
Idioma:
Ru
Ano de publicação:
2009
Tipo de documento:
Article