Interfamily transfer of a plant pattern-recognition receptor confers broad-spectrum bacterial resistance.
Nat Biotechnol
; 28(4): 365-9, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20231819
Plant diseases cause massive losses in agriculture. Increasing the natural defenses of plants may reduce the impact of phytopathogens on agricultural productivity. Pattern-recognition receptors (PRRs) detect microbes by recognizing conserved pathogen-associated molecular patterns (PAMPs). Although the overall importance of PAMP-triggered immunity for plant defense is established, it has not been used to confer disease resistance in crops. We report that activity of a PRR is retained after its transfer between two plant families. Expression of EFR (ref. 4), a PRR from the cruciferous plant Arabidopsis thaliana, confers responsiveness to bacterial elongation factor Tu in the solanaceous plants Nicotiana benthamiana and tomato (Solanum lycopersicum), making them more resistant to a range of phytopathogenic bacteria from different genera. Our results in controlled laboratory conditions suggest that heterologous expression of PAMP recognition systems could be used to engineer broad-spectrum disease resistance to important bacterial pathogens, potentially enabling more durable and sustainable resistance in the field.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças das Plantas
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Plantas Geneticamente Modificadas
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Fenômenos Fisiológicos Bacterianos
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Receptores de Reconhecimento de Padrão
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Imunidade Inata
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article