Privileged scaffolds for library design and drug discovery.
Curr Opin Chem Biol
; 14(3): 347-61, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20303320
ABSTRACT
This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives:
to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bibliotecas de Moléculas Pequenas
/
Descoberta de Drogas
/
Modelos Químicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article