Maduropeptin, a complex of new macromolecular antitumor antibiotics.
J Antibiot (Tokyo)
; 44(4): 403-14, 1991 Apr.
Article
em En
| MEDLINE
| ID: mdl-2032949
ABSTRACT
Maduropeptin, a complex of new macromolecular antitumor antibiotics, is a metabolite of Actinomadura madurae H710-49. The active components maduropeptins A1, A2 and B are acidic chromopeptides with MW of around 22,500 and composed of 14 types of amino acids and an unstable chromophore. The antibiotics are active in vitro against Gram-positive bacteria and highly cytotoxic to tumor cells. They produced significant prolongation of survival time of mice implanted with P388 leukemia and B16 melanoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antibacterianos
/
Antibióticos Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article