The role of 5-HT2A receptor and 5-HT2A/5-HT1A receptor interaction in the suppression of catalepsy.
Genes Brain Behav
; 9(5): 519-24, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20345894
ABSTRACT
In the present study, the 5-HT(2A) and 5-HT(1A) receptors functional activity and 5-HT(2A) receptor gene expression were examined in the brain of ASC/Icg and congenic AKR.CBAD13Mit76C mouse strains (genetically predisposed to catalepsy) in comparison with the parental catalepsy-resistant AKR/J and catalepsy-prone CBA/Lac mouse strains. The significantly reduced 5-HT(2A) receptor functional activity along with decreased 5-HT(2A) receptor gene expression in the frontal cortex was found in all mice predisposed to catalepsy compared with catalepsy-resistant AKR/J. 5-HT(2A) agonist DOI (0.5 and 1 mg/kg, i.p.) significantly reduced catalepsy in ASC/Icg and CBA/Lac, but not in AKR.CBAD13Mit76C mice. Essential increase in 5-HT(1A) receptor functional activity was shown in catalepsy-prone mouse strains in comparison with catalepsy-resistant AKR/J mice. However, in AKR.CBAD13Mit76C mice it was lower than in ASC/Icg and CBA/Lac mice. The inter-relation between 5-HT(2A) and 5-HT(1A) receptors in the regulation of catalepsy was suggested. This suggestion was confirmed by prevention of DOI anticataleptic effect in ASC/Icg and CBA/Lac mice by pretreatment with 5-HT(1A) receptor antagonist p-MPPI (3 mg/kg, i.p.). At the same time, the activation of 5-HT(2A) receptor led to the essential suppression of 5-HT(1A) receptor functional activity, indicating the opposite effect of 5-HT(2A) receptor on pre- and postsynaptic 5-HT(1A) receptors. Thus, 5-HT(2A)/5-HT(1A) receptor interaction in the mechanism of catalepsy suppression in mice was shown.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catalepsia
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Receptor 5-HT1A de Serotonina
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Receptor 5-HT2A de Serotonina
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Lobo Frontal
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article