Uridine enhances expression of the fragile X chromosome in human lymphocytes.
Hum Genet
; 87(1): 95-6, 1991 May.
Article
em En
| MEDLINE
| ID: mdl-2037287
ABSTRACT
We have studied the effect of uridine on the expression of fragile X (fra[X]) in lymphocyte cultures established in the folate and thymidine deficient medium TC199. The results indicate that uridine enhances the expression of fra(X) and gives a higher mitotic rate. The excess of uridine during DNA synthesis might further promote the previously suggested cycle of misincorporation and removal of deoxyuridine monophosphate when the pool of deoxythymidine triphosphate is continuously depleted.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uridina
/
Linfócitos
/
Síndrome do Cromossomo X Frágil
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article