Your browser doesn't support javascript.
loading
Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy.
Foussal, Camille; Lairez, Olivier; Calise, Denis; Pathak, Atul; Guilbeau-Frugier, Celine; Valet, Philippe; Parini, Angelo; Kunduzova, Oksana.
Afiliação
  • Foussal C; Institut National de la Santé et de la Recherche Médicale (INSERM), U858, Toulouse, France.
FEBS Lett ; 584(11): 2363-70, 2010 Jun 03.
Article em En | MEDLINE | ID: mdl-20398658
ABSTRACT
Adipose tissue secretes a variety of bioactive factors, which can regulate cardiomyocyte hypertrophy via reactive oxygen species (ROS). In the present study we investigated whether apelin affects ROS-dependent cardiac hypertrophy. In cardiomyocytes apelin inhibited the hypertrophic response to 5-HT and oxidative stress induced by 5-HT- or H(2)O(2) in a dose-dependent manner. These effects were concomitant to the increase in mRNA expression and activity of catalase. Chronic treatment of mice with apelin attenuated pressure-overload-induced left ventricular hypertrophy. The prevention of hypertrophy by apelin was associated with increased myocardial catalase activity and decreased plasma lipid hydroperoxide, as an index of oxidative stress. These results show that apelin behaves as a catalase activator and prevents cardiac ROS-dependent hypertrophy.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catalase / Cardiomegalia / Estresse Oxidativo / Miócitos Cardíacos / Peróxido de Hidrogênio Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catalase / Cardiomegalia / Estresse Oxidativo / Miócitos Cardíacos / Peróxido de Hidrogênio Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article