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Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III.
Shen, Yongchun; Boivin, Roch; Yoneda, Naoki; Du, Hong; Schiller, Shawn; Matsushima, Tomohiro; Goto, Masaki; Shirota, Hiroshi; Gusovsky, Fabian; Lemelin, Charles; Jiang, Yimin; Zhang, Zhiyi; Pelletier, Robert; Ikemori-Kawada, Megumi; Kawakami, Yoshiyuki; Inoue, Atsushi; Schnaderbeck, Matthew; Wang, Yuan.
Afiliação
  • Shen Y; Eisai Inc., Andover, MA 01810, USA.
Bioorg Med Chem Lett ; 20(10): 3155-7, 2010 May 15.
Article em En | MEDLINE | ID: mdl-20399648
Inspired by natural product, LL-Z1640-2, clinical candidate, E6201 (22) was discovered in a medicinal chemistry effort through total synthesis. The modification on C14-position to N-alkyl substitution showed to be potent in vitro and orally active in vivo in anti-inflammatory assays.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactonas / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lactonas / Anti-Inflamatórios Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article