Pancytopenia due to proguanil toxicity in a returning traveller with fever.
Eur J Clin Pharmacol
; 66(8): 811-2, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20407763
ABSTRACT
A patient known to have renal insufficiency was admitted to the hospital with fever and pancytopenia after returning from a trip to Mali. Pancytopenia was not caused by a tropical infection but was a side effect of atovaquone/proguanil used as malaria chemoprophylaxis. High and prolonged detectable proguanil serum levels can result in bone marrow suppression in patients with renal insufficiency. This should be taken into account in a returning traveller with fever and pancytopenia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pancitopenia
/
Viagem
/
Proguanil
/
Febre
/
Antimaláricos
Limite:
Female
/
Humans
/
Middle aged
País/Região como assunto:
Africa
/
Europa
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article