Tetracyclic sulfones as potent gamma-secretase inhibitors: synthesis and structure-activity relationship studies.
Bioorg Med Chem Lett
; 20(12): 3645-8, 2010 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-20471254
Complex tetracyclic sulfones were designed as gamma-secretase inhibitors and a stereoselective synthesis was achieved. Gamma-secretase activity was seen predominately in the (-) enantiomeric series. Compounds such as 2a and 2b showed remarkable in vitro and in vivo potency.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores de Proteases
/
Sulfonas
/
Secretases da Proteína Precursora do Amiloide
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article