CD163 expression is present in cutaneous histiocytomas but not in atypical fibroxanthomas.
Am J Clin Pathol
; 133(6): 915-21, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20472850
ABSTRACT
CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages. Recent work has shown that this marker is specific for neoplasms of histiocytic differentiation. Our aim was to test the ability of CD163 to separate cutaneous histiocytomas from their morphologic mimics. We tested the expression of CD163 in 78 cases, including 19 xanthogranulomas, 16 atypical fibroxanthomas, 6 reticulohistiocytomas, 8 epithelioid cell histiocytomas, 9 cases of Langerhans cell histiocytosis, 10 xanthomas, and 10 intradermal Spitz nevi. CD163 expression was seen in all xanthogranulomas and reticulohistiocytomas, 4 epithelioid cell histiocytomas, 2 cases of Langerhans cell histiocytosis, and 8 xanthomas but was absent in atypical fibroxanthomas and Spitz nevi. CD163 is an excellent marker for confirming histiocytic differentiation and is useful in eliminating morphologic mimics such as Spitz nevi from the differential diagnosis. The lack of CD163 in atypical fibroxanthomas argues against a histiocytic origin for this tumor.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Antígenos de Diferenciação Mielomonocítica
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Biomarcadores Tumorais
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Antígenos CD
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Histiocitoma Fibroso Benigno
/
Receptores de Superfície Celular
Tipo de estudo:
Observational_studies
Limite:
Adult
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Aged
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Aged80
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Child
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Child, preschool
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Humans
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Infant
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Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article