Copper catalyzed asymmetric propargylation of aldehydes.
J Am Chem Soc
; 132(22): 7600-1, 2010 Jun 09.
Article
em En
| MEDLINE
| ID: mdl-20481453
ABSTRACT
The highly enantio- and regioselective copper catalyzed asymmetric propargylation of aldehydes with a propargyl borolane reagent is reported. The methodology demonstrated broad functional group tolerance and provided high enantioselectivities for aliphatic, vinyl, and aryl aldehydes. The utility of the TMS homopropargylic alcohols was demonstrated by the facile conversion to a chiral dihydropyranone.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Boro
/
Cobre
/
Aldeídos
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article