Treatment completion in latent tuberculosis infection at specialist tuberculosis units in Spain.
Int J Tuberc Lung Dis
; 14(6): 701-7, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20487607
ABSTRACT
SETTING:
Treatment of latent tuberculosis infection (LTBI) is essential for tuberculosis (TB) control in low-prevalence countries. However, the long treatment duration and adverse events frequently result in suboptimal treatment completion.OBJECTIVE:
To determine completion rates of LTBI treatment and to identify risk factors for non-completion of treatment.DESIGN:
Retrospective, observational cohort study.METHODS:
All non-human immunodeficiency virus infected adults who started treatment for LTBI at two specialist TB units in Spain between January 2004 and March 2007 were included. Those who discontinued treatment due to toxicity were excluded.RESULTS:
Of 599 people who started on treatment, 484 (80.8%, 95%CI 77.5-83.8) completed it. Age <36 years (OR 0.33, 95%CI 0.30-0.76, P = 0.001), male sex (OR 0.58, 95%CI 0.37-0.92, P = 0.02), immigrant status <5 years of residence (OR 0.21, 95%CI 0.12-0.37, P < 0.001) and the presence of social risk factors (OR 0.21, 95%CI 0.11-0.39, P < 0.001) were associated with lower rates of treatment completion. Short treatment regimens were not associated with better treatment completion compared with isoniazid for 6-9 months (OR 0.89, 95%CI 0.45-1.80, P = 0.76).CONCLUSIONS:
Overall, completion rates of LTBI treatment in specialist TB units are good. Nevertheless, counselling should be strengthened and new strategies to enhance adherence should be sought for recent immigrants and for people in unfavourable social situations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Latente
/
Hospitais de Doenças Crônicas
/
Antituberculosos
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article