Inducing and maintaining remission in ulcerative colitis: role of high-dose, extended-release mesalamine.
J Clin Gastroenterol
; 44(8): 531-5, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20495466
ABSTRACT
In mild-to-moderate inflammatory bowel disease, particularly ulcerative colitis, 5-aminosalicylic acid (5-ASA) remains a cornerstone of therapy. Sulfasalazine, originally synthesized in 1940 as an arthritis treatment for Sweden's King Gustaf V, is an azo-linked compound between 5-ASA and sulfapyridine. This medication was soon discovered to be effective in treating ulcerative colitis. However, dose-related side effects of the sulfapyridine moiety led to considerable effort in developing medications to deliver 5-ASA to the desired parts of the intestine. The newest generation of 5-ASA medications allows high-dose medication delivery with decreased pill burden, thereby improving patient compliance. This review will describe the pharmacokinetics of various 5-ASA preparations, particularly focusing on high-dose formulations and their role in therapy; will examine current scientific literature; and will review clinical outcomes and safety profiles.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colite Ulcerativa
/
Anti-Inflamatórios não Esteroides
/
Mesalamina
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article