Iron and porphyrin trafficking in heme biogenesis.
J Biol Chem
; 285(35): 26753-26759, 2010 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-20522548
ABSTRACT
Iron is an essential element for diverse biological functions. In mammals, the majority of iron is enclosed within a single prosthetic group heme. In metazoans, heme is synthesized via a highly conserved and coordinated pathway within the mitochondria. However, iron is acquired from the environment and subsequently assimilated into various cellular pathways, including heme synthesis. Both iron and heme are toxic but essential cofactors. How is iron transported from the extracellular milieu to the mitochondria? How are heme and heme intermediates coordinated with iron transport? Although recent studies have answered some questions, several pieces of this intriguing puzzle remain unsolved.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfirinas
/
Heme
/
Ferro
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article