Beta-conglycinin lowers very-low-density lipoprotein-triglyceride levels by increasing adiponectin and insulin sensitivity in rats.
Biosci Biotechnol Biochem
; 74(6): 1250-5, 2010.
Article
em En
| MEDLINE
| ID: mdl-20530915
ABSTRACT
The relationship between insulin sensitivity and the plasma triglyceride-lowering effect induced by beta-conglycinin was investigated. Male Wistar rats (19 weeks old) were fed diets containing casein, soy protein isolate, or beta-conglycinin for 4 weeks. In oral glucose administration, the beta-conglycinin-fed rats showed a significant decrease in the area under the glucose curve (0-60 min) as compared with the casein-fed rats. The hypoglycemic effect was significantly higher in the beta-conglycinin-fed rats than in the casein-fed rats at 30 min after intraperitoneal insulin injection. The liver sterol regulatory element-binding-protein-1 mRNA expression level was significantly lower and the plasma adiponectin concentration was significantly higher in the beta-conglycinin-fed rats than in the casein-fed rats. The hypotriglyceridemic effect of beta-conglycinin depended on a significant decrease in the concentration of very-low-density-lipoprotein triglycerides. These results indicate that beta-conglycinin increases adiponectin levels and improves glucose tolerance. The ability of beta-conglycinin to lower plasma lipid levels might be due to increased insulin sensitivity of the liver.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triglicerídeos
/
Proteínas de Soja
/
Adiponectina
/
Antígenos de Plantas
/
Proteínas de Armazenamento de Sementes
/
Globulinas
/
Insulina
/
Lipoproteínas LDL
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article