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Once a killer, always a killer: from cytotoxic T cell to memory cell.
Lefrançois, Leo; Obar, Joshua J.
Afiliação
  • Lefrançois L; Department of Immunology, Center for Integrated Immunology and Vaccine Research, UCONN Health Center, Farmington, CT 06030 1319, USA. llefranc@neuron.uchc.edu
Immunol Rev ; 235(1): 206-18, 2010 May.
Article em En | MEDLINE | ID: mdl-20536565
The control of the differentiation pathways followed by responding CD8(+) T cells to produce protective memory cells has been intensely studied. Recent developments have identified heterogeneity at the effector cytotoxic T-lymphocyte level within which a bona fide memory cell precursor has emerged. The challenge now is to identify the cellular and molecular factors that control this developmental pathway. This review considers aspects of the regulation of the induction of effectors, the transition of effectors to memory cells, and the dynamics of the memory population.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T Citotóxicos / Citotoxicidade Imunológica / Memória Imunológica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ativação Linfocitária / Linfócitos T Citotóxicos / Citotoxicidade Imunológica / Memória Imunológica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article