2H-pyrano[2,3-f]quinazoline derivatives with platelet antiaggregating and other activities.
Farmaco
; 46(1): 99-110, 1991 Jan.
Article
em En
| MEDLINE
| ID: mdl-2054045
ABSTRACT
The synthesis of some N,N-disubstituted 4-amino-5,6-dihydro-3,8-diphenyl-2H-pyrano[2,3-f]quinazolin- 2-ones by the reaction of phenylchloroketene with a series of N,N-disubstituted (E)-6-aminomethylene-7,8-dihydro-2-phenylquinazolin-5(6H)-ones, followed by dehydrochlorination of the primary adducts with DBN, is described. The methylbenzylamino and diphenylamino derivatives showed platelet antiaggregating activity in vitro superior to that of acetylsalicylic acid. The 1-pyrrolidinyl derivative showed appreciable local anesthetic activity in mice, whereas the whole series of compounds exhibited weak antiinflammatory activity in rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Quinazolinas
/
Inibidores da Agregação Plaquetária
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article