Fecal calprotectin excretion in preterm infants during the neonatal period.
PLoS One
; 5(6): e11083, 2010 Jun 11.
Article
em En
| MEDLINE
| ID: mdl-20552029
ABSTRACT
BACKGROUND:
Fecal calprotectin has been proposed as a non-invasive marker of intestinal inflammation in inflammatory bowel disease in adults and children. Fecal calprotectin levels have been reported to be much higher in both healthy full-term and preterm infants than in children and adults.OBJECTIVE:
To determine the time course of fecal calprotectin (f-calprotectin) excretion in preterm infants from birth until hospital discharge and to identify factors influencing f-calprotectin levels in the first weeks of life, including bacterial establishment in the gut.METHODOLOGY:
F-calprotectin was determined using an ELISA assay in 147 samples obtained prospectively from 47 preterm infants (gestational age, and birth-weight interquartiles 27-29 weeks, and 880-1320 g, respectively) at birth, and at 2-week intervals until hospital discharge. PRINCIPALFINDINGS:
Although median f-calprotectin excretion was 138 microg/g, a wide range of inter- and intra-individual variation in f-calprotectin values (from day 3 to day 78) was observed (86% and 67%, respectively). In multivariate regression analysis, f-calprotectin correlated negatively with ante and per natal antibiotic treatment (p = 0.001), and correlated positively with the volume of enteral feeding (mL/kg/d) (p = 0.009), the need to interrupt enteral feeding (p = 0.001), and prominent gastrointestinal colonization by Clostridium sp (p = 0.019) and Staphylococcus sp (p = 0.047).CONCLUSION:
During the first weeks of life, the high f-calprotectin values observed in preterm infants could be linked to the gut bacterial establishment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
/
Complexo Antígeno L1 Leucocitário
/
Fezes
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
/
Newborn
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article