Functional analysis of human organic cation transporter OCT3 (SLC22A3) polymorphisms.
J Pharmacol Sci
; 113(3): 263-6, 2010.
Article
em En
| MEDLINE
| ID: mdl-20562519
ABSTRACT
We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system. Three SNPs (A116S, T400I, and A439V) exhibited reduced uptake of both [(3)H]histamine and [(3)H]MPP(+), although their protein expressions were detected in the plasma membrane of transfected cells. This study suggests that the OCT3 variants will contribute to inter-individual variations leading to the differences in cationic drug disposition as well as certain disease processes such as hypertension, allergic diseases, and neuropsychiatric diseases by the clearance of endogenous organic cations such as biogenic amines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monoaminas Biogênicas
/
Polimorfismo de Nucleotídeo Único
/
Proteínas de Transporte de Cátions Orgânicos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article