Paraoxonase gene mutations in amyotrophic lateral sclerosis.
Ann Neurol
; 68(1): 102-7, 2010 Jul.
Article
em En
| MEDLINE
| ID: mdl-20582942
ABSTRACT
Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arildialquilfosfatase
/
Esterases
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Esclerose Lateral Amiotrófica
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Mutação
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article