Complexation of tocotrienol with gamma-cyclodextrin enhances intestinal absorption of tocotrienol in rats.
Biosci Biotechnol Biochem
; 74(7): 1452-7, 2010.
Article
em En
| MEDLINE
| ID: mdl-20622447
To determine the bioavailability of tocotrienol complex with gamma-cyclodextrin, the effects of tocotrienol/gamma-cyclodextrin complex on tocotrienol concentration in rat plasma and tissues were studied. Rats were administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. At 3 h after administration, the plasma gamma-tocotrienol concentration of the rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the rats administered tocotrienol and gamma-cyclodextrin. In order to determine the effect of complexation on tocotrienol absorption, rats were injected with Triton WR1339, which prevents the catabolism of triacylglycerol-rich lipoprotein by lipoprotein lipase, and then administered by oral gavage an emulsion containing tocotrienol, tocotrienol with gamma-cyclodextrin, or tocotrienol/gamma-cyclodextrin complex. The plasma gamma-tocotrienol concentration of the Triton-treated rats administered tocotrienol/gamma-cyclodextrin complex was higher than that of the other Triton-treated rats. These results suggest that complexation of tocotrienol with gamma-cyclodextrin elevates plasma and tissue tocotrienol concentrations by enhancing intestinal absorption.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tocotrienóis
/
Gama-Ciclodextrinas
/
Absorção Intestinal
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article