Effect of maternal body mass index on in vitro response to tocolytics in term myometrium.
Am J Obstet Gynecol
; 203(3): 261.e1-5, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20633871
ABSTRACT
OBJECTIVE:
We sought to investigate the effect of body mass index (BMI) on in vitro response to tocolytics. STUDYDESIGN:
Myometrial biopsies were obtained at the time of scheduled cesarean deliveries from term nonlaboring women with BMI < or =29.9 (26.3 +/- 1.3; n = 7), 30-34.9 (31.8 +/- 1.2; n = 16), and > or = 35 (39.5 +/- 4.9; n = 9). Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10(-10) to 10(-5) mol/L) of nifedipine or indomethacin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using 1-way analysis of variance with Tukey post hoc test.RESULTS:
Myometrial response to tocolytics did not differ between the BMI groups. Nifedipine, but not indomethacin, significantly inhibited myometrial contractility independent of BMI.CONCLUSION:
BMI does not affect uterine response to tocolytics in isolated uterine tissue from term nonlaboring women.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Contração Uterina
/
Nifedipino
/
Tocolíticos
/
Índice de Massa Corporal
/
Indometacina
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article