Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.

Anselm, Lilli; Banner, David W; Benz, Jörg; Zbinden, Katrin Groebke; Himber, Jacques; Hilpert, Hans; Huber, Walter; Kuhn, Bernd; Mary, Jean-Luc; Otteneder, Michael B; Panday, Narendra; Ricklin, Fabienne; Stahl, Martin; Thomi, Stefan; Haap, Wolfgang

Anselm, Lilli; Banner, David W; Benz, Jörg; Zbinden, Katrin Groebke; Himber, Jacques; Hilpert, Hans; Huber, Walter; Kuhn, Bernd; Mary, Jean-Luc; Otteneder, Michael B; Panday, Narendra; Ricklin, Fabienne; Stahl, Martin; Thomi, Stefan; Haap, Wolfgang.

Afiliação

Anselm L; F. Hoffmann-La Roche Ltd, Pharma Research, Basel, Switzerland.

Bioorg Med Chem Lett ; 20(17): 5313-9, 2010 Sep 01.

Article em En | MEDLINE | ID: mdl-20650636

Assuntos

Inibidores do Fator Xa; Pirrolidinas/farmacologia; Pirrolidinas/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Inibidores do Fator Xa Idioma: En Ano de publicação: 2010 Tipo de documento: Article

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