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Immune regulation by peripheral suppressor T cells induced upon homotypic T cell/T cell interactions.
Thümmler, Katja; Leipe, Jan; Ramming, Andreas; Schulze-Koops, Hendrik; Skapenko, Alla.
Afiliação
  • Thümmler K; University of Munich, Pettenkoferstrasse 8a, Munich, Germany. alla.skapenko@med.uni-muenchen.de
J Leukoc Biol ; 88(5): 1041-50, 2010 Nov.
Article em En | MEDLINE | ID: mdl-20651300
We have shown previously that homotypic interaction of resting memory CD4 T cells with activated T cells induces the production of cytokines with immunoregulatory potential (IL-10, IL-4) from the former. Here, we analyzed the effector functions of these T cells stimulated by homotypic T cell interaction. T cells induced upon homotypic T cell interaction expressed CD25 and reduced levels of CD127 and produced TGF-ß. Functionally, homotypic T cell interaction-induced T cells were anergic and inhibited the proliferation of CD25-negative T cells as potently as naturally occurring CD25-positive Tregs in vitro. They also prevented clonotypic expansion of OVA TCR tg T cells in BALB/c mice upon antigenic challenge in vivo. The generation of suppressor T cells by homotypic T cell contact is anchored and tuned through interactions of LFA-1 and its ligands ICAM-1, ICAM-2, and ICAM-3. Together, the data suggest a negative-feedback mechanism of specific immunity involving bystander-activated memory T cells.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Linfócitos T CD4-Positivos Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Linfócitos T CD4-Positivos Limite: Animals / Humans Idioma: En Ano de publicação: 2010 Tipo de documento: Article