The assessment of efficacy of Diascorea alata for menopausal symptom treatment in Taiwanese women.
Climacteric
; 14(1): 132-9, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20653397
ABSTRACT
OBJECTIVE:
The aim of this study was to assess the efficacy and safety of Diascorea alata for treatment of menopausal symptoms. MATERIALS ANDMETHODS:
Two-center, randomized, double-blind, placebo-controlled clinical investigation on 50 menopausal women randomly assigned to two groups, treated for 12 months with either placebo or two sachets daily of Diascorea extracts containing 12 mg/sachet. Primary outcome measures were changes in the Greene Climacteric Scale caused by Diascorea compared with placebo; secondary outcomes were changes in plasma hormone profiles. One-way ANCOVA test was performed to investigate the significance.RESULTS:
At 6 months and at the end of treatment, those women who received Diascorea showed general improvement in almost all the clinical symptoms investigated. A significant reduction was noted in the total Greene scores in the Diascorea group assessed at the end of 12 months' treatment (pâ<â0.01). This phenomenon was more significant for the psychological parameters of anxiety than for other parameters. Apparent improvements were noted in the parameters 'feeling tense or nervous' (pâ=â0.007), 'insomnia' (pâ=â0.004), 'excitable' (pâ=â0.047) and 'musculoskeletal pain' (pâ=â0.019) among those receiving Diascorea. Diascorea consumption also resulted in positive effects on blood hormone profiles.CONCLUSIONS:
Compared with placebo, Diascorea alata improves symptoms, particularly the psychological parameters in menopausal women. Safety monitoring indicated that standardized extracts of Diascorea alata were safe during daily administration over a period of 12 months.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Climatério
/
Medicamentos de Ervas Chinesas
/
Dioscorea
/
Fitoterapia
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Female
/
Humans
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article