Allicin and derivates are cysteine protease inhibitors with antiparasitic activity.
Bioorg Med Chem Lett
; 20(18): 5541-3, 2010 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-20692829
ABSTRACT
Allicin and derivatives thereof inhibit the CAC1 cysteine proteases falcipain 2, rhodesain, cathepsin B and L in the low micromolar range. The structure-activity relationship revealed that only derivatives with primary carbon atom in vicinity to the thiosulfinate sulfur atom attacked by the active-site Cys residue are active against the target enzymes. Some compounds also show potent antiparasitic activity against Plasmodium falciparum and Trypanosoma brucei brucei.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Ácidos Sulfínicos
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Trypanosoma brucei brucei
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Inibidores de Cisteína Proteinase
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Antiparasitários
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article