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Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c.
Lee, IkSoo; Kim, JinPyo; Ryoo, InJa; Kim, YoungHee; Choo, SooJin; Yoo, IckDong; Min, ByungSun; Na, MinKyun; Hattori, Masao; Bae, KiHwan.
Afiliação
  • Lee I; College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.
Bioorg Med Chem Lett ; 20(18): 5577-81, 2010 Sep 15.
Article em En | MEDLINE | ID: mdl-20702092
Several lanostane triterpenes [butyl ganoderate A (1), butyl ganoderate B (2), butyl lucidenate N (3), and butyl lucidenate A (4)] bearing a butyl ester side chain from the fruiting bodies of Ganoderma lucidum exhibited considerable inhibitory effects on adipogenesis in 3T3-L1 cells. The inhibitory mechanism of 1 and 3 on adipogenesis in 3T3-L1 cells was investigated; we found that the mRNA and protein expression levels of SREBP-1c were reduced by treatment with 1 and 3 versus the untreated control. Furthermore, compounds 1 and 3 suppressed the mRNA expression levels of FAS and ACC. These results demonstrate that inhibition of adipogenesis in 3T3-L1 cells by treatment with 1 and 3 may be mediated in part through down-regulation of the adipogenic transcription factor SREBP-1c and its target genes, such as FAS and ACC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Regulação para Baixo / Reishi / Células 3T3-L1 / Proteína de Ligação a Elemento Regulador de Esterol 1 / Adipogenia Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Regulação para Baixo / Reishi / Células 3T3-L1 / Proteína de Ligação a Elemento Regulador de Esterol 1 / Adipogenia Limite: Animals Idioma: En Ano de publicação: 2010 Tipo de documento: Article