The roles of antigen-specificity, responsiveness to transforming growth factor-ß and antigen-presenting cell subsets in tumour-induced expansion of regulatory T cells.
Immunology
; 131(4): 556-69, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20722761
ABSTRACT
In this study we investigated the impact of several factors on the expansion of natural regulatory T (nTreg) cells by tumours, including antigen specificity, transforming growth factor-ß (TGF-ß) signalling and the antigen-presenting cell subsets responsible for expansion. We found that antigen non-specific expansion of nTreg cells is tumour cell line-dependent. Although both antigen-specific and non-specific pathways can contribute to expansion, the migration of activated nTreg cells to tumour tissues is strictly antigen-dependent. Intact TGF-ß signalling on nTreg cells is also essential for tumour-induced expansion. Finally, for stimulation of resting antigen-specific CD4 T cells, CD11c(+) cells purified from tumour-draining lymph nodes were more potent than CD11b(+) cells, suggesting that dendritic cells are the key antigen-presenting cell subset involved in cross-presentation of tumour antigens. This study not only provides an in vivo system in which cross-talk between nTreg cells and tumours can be explored but also reveals novel aspects of tumour immune evasion.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Transformador beta
/
Linfócitos T Reguladores
/
Evasão Tumoral
/
Apresentação Cruzada
/
Proliferação de Células
/
Células Apresentadoras de Antígenos
/
Antígenos de Neoplasias
/
Neoplasias
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article