CD8+ T cell recognition of cryptic epitopes is a ubiquitous feature of AIDS virus infection.
J Virol
; 84(21): 11569-74, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20739530
ABSTRACT
Vaccines designed to elicit AIDS virus-specific CD8+ T cells should engender broad responses. Emerging data indicate that alternate reading frames (ARFs) of both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode CD8+ T cell epitopes, termed cryptic epitopes. Here, we show that SIV-specific CD8+ T cells from SIV-infected rhesus macaques target 14 epitopes in eight ARFs during SIV infection. Animals recognized up to five epitopes, totaling nearly one-quarter of the anti-SIV responses. The epitopes were targeted by high-frequency responses as early as 2 weeks postinfection and in the chronic phase. Hence, previously overlooked ARF-encoded epitopes could be important components of AIDS vaccines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Imunodeficiência Adquirida dos Símios
/
Vacinas contra a SAIDS
/
Linfócitos T CD8-Positivos
/
Epitopos de Linfócito T
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article