Hydoroxyhibiscone A, a novel human neutrophil elastase inhibitor from Hibiscus syriacus.
J Microbiol Biotechnol
; 20(8): 1189-91, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20798580
ABSTRACT
In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to possess significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 micronM, respectively.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Elastase de Leucócito
/
Hibiscus
/
Proteínas Secretadas Inibidoras de Proteinases
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article