Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis.
J Allergy Clin Immunol
; 126(6): 1163-9.e5, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20810159
ABSTRACT
BACKGROUND:
Allergic rhinitis is a global health problem that causes major illnesses and disability worldwide. Allergen-specific immunotherapy (SIT) is the only available treatment that can alter the natural course of allergic disease. However, the precise mechanism underlying allergen-SIT is not well understood.OBJECTIVE:
The aim of the current study was to identify protein expression signatures reflective of allergen-SIT-more specifically, sublingual immunotherapy (SLIT).METHODS:
Serum was taken twice from patients with seasonal allergic rhinitis caused by Japanese cedar once before the pollen season and once during the season. A total of 25 patients was randomly categorized into a placebo-treated group and an active-treatment group. Their serum protein profiles were analyzed by 2-dimensional electrophoresis.RESULTS:
Sixteen proteins were found to be differentially expressed during the pollen season. Among the differentially expressed proteins, the serum levels of complement C4A, apolipoprotein A-IV (apoA-IV), and transthyretin were significantly increased in SLIT-treated patients but not in placebo-treated patients. Among these proteins, the serum levels of apoA-IV correlated with the clinical symptom-medication scores (r = -0.635; P < .05) and with quality of life scores (r = -0.516; P < .05) in the case of SLIT-treated patients. The amount of histamine released from the basophils in vitro was greatly reduced after the addition of recombinant apoA-IV in the medium (P < .01).CONCLUSION:
Our data will increase the understanding of the mechanism of SLIT and may provide novel insights into the treatment of allergic rhinitis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas A
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Pré-Albumina
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Complemento C4a
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Rinite Alérgica Sazonal
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Dessensibilização Imunológica
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Prognostic_studies
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article