Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study.
Arch Gen Psychiatry
; 67(9): 889-94, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20819982
ABSTRACT
CONTEXT Clues from the epidemiology of schizophrenia suggest that low levels of developmental vitamin D may be associated with increased risk of schizophrenia. OBJECTIVE:
To directly examine the association between neonatal vitamin D status and risk of schizophrenia.DESIGN:
Individually matched case-control study drawn from a population-based cohort.SETTING:
Danish national health registers and neonatal biobank.PARTICIPANTS:
A total of 424 individuals with schizophrenia and 424 controls matched for sex and date of birth. MAIN OUTCOMEMEASURES:
The concentration of 25 hydroxyvitamin D(3) (25[OH]D3) was assessed from neonatal dried blood samples using a highly sensitive liquid chromatography tandem mass spectroscopy method. Relative risks were calculated for the matched pairs when examined for quintiles of 25(OH)D3.RESULTS:
Compared with neonates in the fourth quintile (with 25[OH]D3 concentrations between 40.5 and 50.9 nmol/L), those in each of the lower 3 quintiles had a significantly increased risk of schizophrenia (2-fold elevated risk). Unexpectedly, those in the highest quintile also had a significantly increased risk of schizophrenia. Based on this analysis, the population-attributable fraction associated with neonatal vitamin D status was 44%. The relationship was not explained by a wide range of potential confounding or interacting variables.CONCLUSIONS:
Both low and high concentrations of neonatal vitamin D are associated with increased risk of schizophrenia, and it is feasible that this exposure could contribute to a sizeable proportion of cases in Denmark. In light of the substantial public health implications of this finding, there is an urgent need to further explore the effect of vitamin D status on brain development and later mental health.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Vitamina D
/
Recém-Nascido
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article