High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man.
Pharm Weekbl Sci
; 12(6): 243-6, 1990 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-2091020
ABSTRACT
A direct high pressure liquid chromatographic analysis of sulfaphenazole-N2-glucuronide in urine is described. After an oral dose of 439 mg of sulfaphenazole, 0% is excreted unchanged in the urine, less than 1% is excreted as N4-acetylsulfaphenazole. As N2-glucuronide 49.4% is excreted in one slow acetylator and 84.8% in one fast acetylator.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfafenazol
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article