Mice lacking alpha/beta and gamma interferon receptors are susceptible to junin virus infection.
J Virol
; 84(24): 13063-7, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20926559
ABSTRACT
Junin virus (JUNV) causes a highly lethal human disease, Argentine hemorrhagic fever. Previous work has demonstrated the requirement for human transferrin receptor 1 for virus entry, and the absence of the receptor was proposed to be a major cause for the resistance of laboratory mice to JUNV infection. In this study, we present for the first time in vivo evidence that the disruption of interferon signaling is sufficient to generate a disease-susceptible mouse model for JUNV infection. After peripheral inoculation with virulent JUNV, adult mice lacking alpha/beta and gamma interferon receptors developed disseminated infection and severe disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Interferon
/
Vírus Junin
/
Infecções por Arenaviridae
/
Suscetibilidade a Doenças
/
Receptor de Interferon alfa e beta
Limite:
Animals
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article