Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain.
Bioorg Med Chem Lett
; 20(22): 6379-83, 2010 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-20934334
ABSTRACT
A novel series of pyrazole sEH inhibitors is reported. Lead optimization efforts to replace the aniline core are also described. In particular, 2-pyridine, 3-pyridine and pyridazine analogs are potent sEH inhibitors with favorable CYP3A4 inhibitory and microsomal stability profiles.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Inibidores Enzimáticos
/
Epóxido Hidrolases
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article