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Coffee and cancers of the upper digestive and respiratory tracts: meta-analyses of observational studies.
Turati, F; Galeone, C; La Vecchia, C; Garavello, W; Tavani, A.
Afiliação
  • Turati F; Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan; Department of Occupational Health "Clinica del Lavoro Luigi Devoto", Section of Medical Statistics "Giulio A. Maccacaro", Università degli Studi di Milano, Milan.
  • Galeone C; Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan; Department of Occupational Health "Clinica del Lavoro Luigi Devoto", Section of Medical Statistics "Giulio A. Maccacaro", Università degli Studi di Milano, Milan.
  • La Vecchia C; Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan; Department of Occupational Health "Clinica del Lavoro Luigi Devoto", Section of Medical Statistics "Giulio A. Maccacaro", Università degli Studi di Milano, Milan.
  • Garavello W; Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan; Department of Otorhinolaryngology, Università degli Studi di Milano-Bicocca, Monza, Italy.
  • Tavani A; Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan. Electronic address: alessandra.tavani@marionegri.it.
Ann Oncol ; 22(3): 536-544, 2011 Mar.
Article em En | MEDLINE | ID: mdl-20943597
BACKGROUND: Data of epidemiological studies on the relation between coffee drinking and upper aerodigestive tract cancer risk are scattered and inconclusive. We therefore conducted systematic meta-analyses of observational studies published before October 2009. MATERIALS AND METHODS: We combined relative risks (RR) with 95% confidence intervals (CI) for cancers of the oral cavity/pharynx (OP) and larynx, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), comparing the highest versus the lowest categories of coffee consumption, using random-effects models. RESULTS: For OP cancer, the pooled RR was 0.64 (95% CI 0.51-0.80) for highest versus lowest coffee drinking, based on a total of 2633 cases from one cohort and eight case-control studies, with no significant heterogeneity across studies. The RRs were 0.61 (95% CI 0.41-0.89) for European, 0.58 (95% CI 0.36-0.94) for American and 0.74 (95% CI 0.48-1.15) for Asian studies, where coffee consumption is lower. The corresponding RRs were 1.56 (95% CI 0.60-4.02) for laryngeal cancer (732 cases from three case-control studies), 0.87 (95% CI 0.65-1.17) for ESCC (2115 cases from one cohort and six case-control studies) and 1.18 (95% CI 0.81-1.71) for EAC (415 cases from three case-control studies). CONCLUSION: Coffee drinking is inversely related to OP cancer risk, while there is no relation with laryngeal cancer, ESCC and EAC.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Respiratório / Café / Neoplasias Gastrointestinais Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans / Male Idioma: En Ano de publicação: 2011 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Respiratório / Café / Neoplasias Gastrointestinais Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans / Male Idioma: En Ano de publicação: 2011 Tipo de documento: Article