Vba2p, a vacuolar membrane protein involved in basic amino acid transport in Schizosaccharomyces pombe.
Biosci Biotechnol Biochem
; 74(10): 2166-9, 2010.
Article
em En
| MEDLINE
| ID: mdl-20944394
ABSTRACT
A recent study filling the gap in the genome sequence in the left arm of chromosome 2 of Schizosaccharomyces pombe revealed a homolog of budding yeast Vba2p, a vacuolar transporter of basic amino acids. GFP-tagged Vba2p in fission yeast was localized to the vacuolar membrane. Upon disruption of vba2, the uptake of several amino acids, including lysine, histidine, and arginine, was impaired. A transient increase in lysine uptake under nitrogen starvation was lowered by this mutation. These findings suggest that Vba2p is involved in basic amino acid transport in S. pombe under diverse conditions.
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Assunto principal:
Proteínas de Membrana Transportadoras
/
Schizosaccharomyces
/
Aminoácidos Básicos
/
Proteínas de Schizosaccharomyces pombe
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article