S-Adenosylmethionine-dependent radical-based modification of biological macromolecules.
Curr Opin Struct Biol
; 20(6): 684-92, 2010 Dec.
Article
em En
| MEDLINE
| ID: mdl-20951571
ABSTRACT
Proteins and RNA molecules enjoy a variety of chemically complex post-translational and post-transcriptional modifications. The chemistry at work in these reactions, which was considered to be exclusively ionic in nature has recently been shown to depend on radical mechanisms in some cases. The overwhelming majority of these radical-based reactions are catalyzed by 'Radical-SAM' enzymes. This review article highlights mechanistic and structural aspects of this class of reactions and indicates important research directions to be addressed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
S-Adenosilmetionina
/
RNA
/
Proteínas
/
Enzimas
/
Radicais Livres
Limite:
Humans
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article