The secreted integrin ligand nephronectin is necessary for forelimb formation in Xenopus tropicalis.
Dev Biol
; 349(2): 204-12, 2011 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-20977901
ABSTRACT
While limb regeneration has been extensively studied in amphibians, little is known about the initial events in limb formation in metamorphosing anurans. The small secreted integrin ligand nephronectin (npnt) is necessary for development of the metanephros in mouse. Although expressed in many tissues, its role in other developmental processes is not well-studied. Here we show that a transgene insertion that disrupts this gene ablates forelimb formation in Xenopus tropicalis. Our results suggest a novel role for integrin signalling in limb development, and represent the first insertional phenotype to be cloned in amphibians.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Xenopus
/
Transdução de Sinais
/
Proteínas da Matriz Extracelular
/
Regulação da Expressão Gênica no Desenvolvimento
/
Membro Anterior
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article